HIF1A-AS2 induces osimertinib resistance in lung adenocarcinoma patients by regulating the miR-146b-5p/IL-6/STAT3 axis
Although epidermal growth factor receptor tyrosine kinase inhibitors Horse Leg Wraps (TKIs) show efficacy in lung adenocarcinoma (LUAD) patients, TKI resistance inevitably develops, limiting long-term results.Thus, there is an urgent need to address drug resistance in LUAD.Long non-coding RNA (lncRNA) HIF1A-AS2 could be a critical mediator in the p