HIF1A-AS2 INDUCES OSIMERTINIB RESISTANCE IN LUNG ADENOCARCINOMA PATIENTS BY REGULATING THE MIR-146B-5P/IL-6/STAT3 AXIS

HIF1A-AS2 induces osimertinib resistance in lung adenocarcinoma patients by regulating the miR-146b-5p/IL-6/STAT3 axis

Although epidermal growth factor receptor tyrosine kinase inhibitors Horse Leg Wraps (TKIs) show efficacy in lung adenocarcinoma (LUAD) patients, TKI resistance inevitably develops, limiting long-term results.Thus, there is an urgent need to address drug resistance in LUAD.Long non-coding RNA (lncRNA) HIF1A-AS2 could be a critical mediator in the p

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Establishment of Biocontrol Agents and Their Impact on Rhizosphere Microbiome and Induced Grapevine Defenses Are Highly Soil-Dependent

With a reduction in available chemical treatments, there is an increased interest in biological control of grapevine trunk diseases.Few studies have investigated the impact of introducing beneficial microorganisms in the rhizosphere on the existing indigenous soil microbiome.In this study, we explored the effect of two biocontrol agents (BCAs), Tri

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Behind every great research project is great data management

Abstract Research data management (RDM) is the cornerstone of a successful research project, and yet it often remains an underappreciated art that gets overlooked in the hustle and bustle of everyday project management even when required by funding bodies.If researchers are to strive for reproducible science that adheres to the principles of FAIR,

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